What does this rating mean?
Lion’s Mane (Hericium erinaceus) is a type of edible mushroom. It grows as a clump of spines and is named for its similar appearance to the mane of a lion. It can be eaten cooked, and is also available in a range of supplements (including tablets and powders). It is used in traditional Asian medicine.
Studies have found that compounds in lion’s mane can stimulate the production of nerve growth factor (NGF). NGF is involved in the growth and maintenance of nerve cells in the brain. It is though that lion’s mane may be able to influence mood by increasing the amount of NGF in the brain.
There is very little scientific evidence on lion’s mane for the treatment of depression. One study treated women experiencing menopause symptoms with either lion’s mane or a placebo (sham treatment) for four weeks. Both the women who received lion’s mane and those who received the placebo experienced a reduction in depression symptoms. The size of the study was small, and it is unclear if any participants had clinical depression.
A second small study looked the use of lion’s mane in people with obesity, some of whom had depression. This study found that participants who took lion’s mane had improvements in depression symptoms, however there was no placebo comparison group and the size of the study was small.
More studies of better quality are needed to understand the effectiveness of lion’s mane for depression.
Like all dietary supplements, lion’s mane may have negative interactions with prescribed medications or other supplements. It should be taken under the supervision of a health care professional.
Lion’s mane supplements can be purchased from supplement stores and health food retailers.
Given the lack of evidence on lion’s mane, it cannot be recommended as a treatment for depression.
Last reviewed and updated: 7 September 2023