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BluePages Depression Information

Ketamine

Our rating
 !1 smiley: This treatment is promising and may be useful. It has some evidence to support it, but more evidence is needed to be sure it works.

What is it?

Ketamine is an anesthetic medication, usually used in surgical settings to sedate patients. It has been researched as fast-acting antidepressant, usually for patients who don’t respond well to other forms of treatment. Ketamine is also used as an illegal recreational drug.

How does it work?

Ketamine is usually given as an intravenous (IV) fluid by a doctor in hospital. The dose used is lower than what would be given to produce anesthetic effects. Ketamine is thought to work by blocking certain receptors in the brain that are involved in cell growth, which may be over-active in people with depression.

Is it effective?

There is some scientific evidence on ketamine for the treatment of depression. While more studies of better quality are needed, the current evidence is promising. Patients who have been given low-dose ketamine in hospital often report fast acting (within hours) improvement in their depression symptoms. This in in contrast to typical antidepressant drugs, which usually take many weeks to produce an effect. There is no research looking at the long term effectiveness of ketamine.

Are there any disadvantages?

There are some side effects of ketamine, such as feeling dizzy, confused, and out of touch with reality. Currently, ketamine for depression is administered via IV line in a hospital setting and patients have to be monitored for some time afterwards. Ketamine must be given under medical supervision.

Where do you get it?

The use of ketamine as a treatment for depression is still experimental and mostly limited to hospital settings or as part of clinical trials.

Recommendation

More research is needed, but ketamine may be a useful fast-acting antidepressant in the future.

Ketamine is currently classed as a controlled drug in Australia, and unauthorised possession or use may result in criminal penalties.

Key references

  • Aan Het Rot M1, Zarate CA Jr, Charney DS, Mathew SJ. Ketamine for depression: where do we go from here? Biol Psychiatry. 2012 Oct 1;72(7):537-47.
  • McGirr A, Berlim MT, Bond DJ, Fleck MP, Yatham LN, Lam RW. A systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials of ketamine in the rapid treatment of major depressive episodes. Psychol Med. 2015 Mar;45(4):693-704.
  • Fond G, Loundou A, Rabu C, Macgregor A, Lançon C, Brittner M, et al. Ketamine administration in depressive disorders: a systematic review and meta-analysis. Psychopharmacology (Berl). 2014 Sep;231(18):3663-76.

Last updated and reviewed: 1 December 2016